ESTABLISHING
AN EXPERIMENTAL MODEL
Title.
Development of an experimental model of the
transport of radioactive isotopes that can imitate the characteristics
observed in vivo
Background.
On the basis of the results already obtained,
the hypothesis of the research team is that sodium pertechnetate
is transported through the K-channels by means of an electrical
mechanism similar to that of capillary electrophoresis .
A way of providing data that can support or modify that hypothesis
consists of developing an experimental (artificial) model
outside of the living organism.
If the behavior of the different radioactive isotopes in
the experimental model and in the living organism is similar,
the existing hypothesis will be reinforced. Otherwise, it
will have to be reconsidered.
Objective.
To obtain data on the mechanism of the substances'
movement through the K-channels.
Methodology.
Perform capillary electrophoresis of the
radioactive substances injected in the experiments made in
living organisms, as in 131I, 201T1, 186Rhenium, MIBI and
Tc-99m. Which move and which do not was observed in this experimental
model and their behavior was compared with that observed following
the injection of the same substances in the living organism.
Participants, along with the Science Department
of the Kovacs Foundation.
Department of Analytic Chemistry and Central
Services of the Universidad Central of Barcelona.
Funded in full by the Kovacs Foundation.
Status.
On hold.
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