INFLUENCE
OF THE CHEMICAL CHARACTERISTICS OF THE SUBSTANCES IN THEIR
MIGRATION
Title.
Study of the characteristics of subcutaneous
migration of various substances and different chemical components
of the same substance, hypodermically injected in points of
low electrical resistance in the human being.
Background.
The hypothesis established today about the
transport of substances through K-channels posits that the
mechanism causing it is essentially electric and similar to
that of capillary
electrophoresis . If this were so, the transport characteristics
for different chemical components should be different from
those composed with different electrical characteristics.
Objective.
To study the characteristics of the possible
subcutaneous migration of different composites of Indium,
of different ionic radius, electrical charge, molecular weight
and specific activity.
Methodology.
A total of 16 experiments are performed on
8 healthy subjects (2 different experiments per subject) who
were informed, verbally and in writing, about the nature of
the study and who signed a written informed consent.
The first experiment consisted of subcutaneous injection,
at a depth of 4 mm, 7.4 Mbq of Indium in the form of Chloride,
contained in a volume of 0.125 ml, in a point localized on
the back side of the wrist, and defined by its low electrical
resistance compared to the subject's ear. A static and a dynamic
study were made of its longitudinal migration; if migration
was observed at 5 minutes, a radioactive ring was placed and
a SPEC was performed to assess the depth of migration.
The second experiment had an analogous scheme to the first;
after the injection of 7.4 Mbq of Indium in the form of Oxine.
The fundamental variable was that of the migration (whether
or not) and also, gender, age, size, weight, diameter of wrist
and blood pressure (before and after the experiments) of the
subjects of the study. In these experiments, an Elscint Apex
SP-6HR tomogrammacamera was used, connected on-line to an
Elscint Apex SPX computer with 5.3 version software.
Participants, along with the Foundation's
Science Department.
Department of Nuclear Medicine at the Son
Dureta Hospital (Palma de Mallorca).
Funded in full by the Kovacs Foundation.
Status.
On hold, until obtaining the funds necessary
to resume the study.
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